Research of serum pepsinogen and Helicobacter pylori-IgG antibody in the screening of atrophic gastritis
10.3760/cma.j.issn.1673-4904.2013.01.012
- VernacularTitle:血清胃蛋白酶原及幽门螺杆菌-IgG抗体在查萎缩性胃炎中的作用研究
- Author:
Bing ZHAO
- Publication Type:Journal Article
- Keywords:
Pepsinogens;
Helicobacter pylori;
Antibodies;
Gastritis,atrophic
- From:
Chinese Journal of Postgraduates of Medicine
2013;(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the use of serum pepsinogen(PG) and Helicobacter pylori(Hp)-IgG antibody in the screening of atrophic gastritis.Methods A total of 222 patients were divided into two groups according to the gastroscopy results:159 cases in observation group(atrophic gastritis) and 63 cases in control group(non-atrophic gastritis).Patients in observation group were divided into gastric antrum group(50cases),gastric body group (71 cases) and full stomach multifocal group (3 8 cases) according to shrinking parts.The serum PG Ⅰ and PG Ⅱ was determined by enzyme linked immunosorbent assay method,and PGR (PG Ⅰ / PG Ⅱ) was calculated.The serum Hp-IgG antibody was examined by qualitative analysis.Results The serum PG Ⅰ and PGR was (57.82 ± 23.15) μ g/L,4.41 ± 1.82 in observation group,which was lower than that in control group[(125.04 ± 29.36) μ g/L,10.10 ± 2.01],and there was significant difference (P ＜0.01).The positive rate of the serum Hp-IgG antibody was 86.16％(137/159) in observation group,which was higher than that in control group [53.97％ (34/63)],and there was significant difference (P ＜ 0.01).There was significant difference in the serum PG Ⅰ and PGR between gastric antrum group and gastric body group,full stomach multifocal group (P ＜ 0.01).There was no significant difference in the serum PG Ⅰ and PGR among different atrophy degree in gastric antrum group(P＞ 0.05),but there was significant difference in the serum PG Ⅰ and PGR among different atrophy degree in gastric body group and full stomach multifocal group (P ＜ 0.01).Conclusions The serum PG Ⅰ and PGR and Hp-IgG antibody is related to atrophic gastritis.They are helpful to the screening of atrophic gastritis.
