The prospective clinical study on the influencing factors of gastrointestinal bleeding in secondary prevention patients with cerebral ischemic stroke
10.3760/cma.j.issn.1008-1372.2013.01.016
- VernacularTitle:缺血性脑卒中二级预防患者消化道出血影响因素的前瞻性研究
- Author:
Xiaohong JIN
;
Haibo CAI
;
Li ZHANG
;
Guobin XU
;
Jinqiang ZHU
- Publication Type:Journal Article
- Keywords:
Stroke/prevention & control;
Stroke/complications;
Gastrointestinal hemorrhage;
Risk factors;
Prospective studies
- From:
Journal of Chinese Physician
2013;(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors of gastrointestinal bleeding(GB) in secondary prevention patients with cerebral ischemic stroke(CIS).Methods A total of 616 patients were divided into bleeding group and control group according to the status (yes,no) of suffering GB during the 2years follow-up.Single factor analysis and Logistic regression analysis was used to explore the influencing factors of GB in CIS patients.Results The proportion of age≥65,a history of GB,gastric disease,renal insufficiency,sudden onset,NIHSS ≥12 and CIS ≥2 in the bleeding group was significantly higher than that in the control group (P ＜ 0.05) ; The proportion of combined with statins,proton pump inhibitors and gastric mucosal protective agent in the bleeding group was significantly lower than that in the control group (P ＜0.05) ; The Logistic regression analysis showed that age≥65,a history of GB,gastric disease,renal insufficiency,sudden onset,NIHSS≥12 and the times of CIS≥2 were risk factors of GB; however,combined with statins,proton pump inhibitors were protective factors.Conclusions Aging,a history of GB,gastric disease,sudden onset,higher NIHSS score and the times of CIS ≥ 2 were the risk factors of GB,combined with statins and proton pump inhibitors could reduce the risk of GB.
