study of C reactive protein up-regulating monocyte chemotactic protein-1 expression in Metabolic Syndrome
- VernacularTitle:代谢综合征患者炎症反应C反应蛋白对单核细胞趋化蛋白-1表达的影响
- Author:
Huidong LONG
;
Yunen LIN
;
Liying LIANG
;
Zhaohua ZENG
;
Minjuan LIU
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome(MS);
C reactive protein(CRP);
Insulin resistance(IR);
Monocyte chemotactic protein-1 (MCP-1)
- From:
Journal of Chinese Physician
2012;(z1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between high sensitive C reactive protein(hsCRP) and monocyte chemotactic protein-1 (MCP-1) in patients with metabolic syndrome(MS).Methods Sixty-two patients with MS and 52 normal healthy individuals (NS) were recruited in the study.And the levels of hs-CRP and MCP-1 were detected by ELISA.The severity of Insulin resistance was calculated by homeostasismodel assessment of insulin resistance(HOMA-IR).The monocytes in blood were isolated,cultured and stimulated by different concentrations of CRP.MCP-lexpression of monocytes was measured by real-time PCR.Results Patients with MS displayed significantly higher serum levels of hs-CRP and MCP-1 compared with healthy control group [(80.26 ±35.52) nmol/L vs (3.12 ±2.55) nmol/L for hs-CRP,P ＜0.01 ; (15.35 ± 10.12) nmol/L vs (9.76 ± 6.15) nmol/L for MCP-1,P ＜ 0.05].There was significantly positive correlation between hs-CRP and MCP-1.Serum hs-CRP,MCP-1and insulin resistance index were positively correlated,respectively.In vitro experiments indicated that CRP could up-regulate MCP-1 expression of monocytes in a concentration-dependent way.When the concentration of CRP was 176nmol/L,the expression of MCP-1 could reach 105％ compared with non-stimulated group.Conclusion With the severity of the inflammatory response and enhanced insulin resistance,elevated serum CRP level may result in MCP-1 expression in patients with metabolic syndrome.
