The changes and significance of integrin α4β7 and L-selectin levels in critical children
10.3760/cma.j.issn.1673-4904.2013.04.002
- VernacularTitle:危重症患儿整合素α4β7和L-选择素水平变化及其意义探讨
- Author:
Yongqian CHEN
;
Aihua WANG
;
Yanhong WU
;
Baoquan ZHU
- Publication Type:Journal Article
- Keywords:
Critical illness;
L-selectin;
Gastrointestinal dysfunction;
Integrin α 4 β 7
- From:
Chinese Journal of Postgraduates of Medicine
2013;(4):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes ofintegrin α4β7 and L-selectin levels and the possible relationship between the changes and intestinal mucosal immune function in critical children with gastrointestinal dysfunction.Methods Forty-eight admitted critical children were divided into non-gastrointestinal dysfunction group (29 cases) and gastrointestinal dysfunction group (19 cases),and also compared with 25 healthy people (control group).The expression of integrin α 4β 7 and L-selectin was measured by flow cytometry.Results The expression of integrin α 4β 7 in gastrointestinal dysfunction group [(11.11 ± 1.15)％] was lower than that in non-gastrointestinal dysfunction group [(15.36 ± 1.26)％]and control group [(19.62 ±0.89)％] (P ＜0.05),but there was no significant difference between nongastrointestinal dysfunction group and control group(P ＞ 0.05).The expression of L-selectin in gastrointestinal dysfunction group [(60.68 ±3.72)％] was lower than that in non-gastrointestinal dysfunction group [(69.43 ± 1.52)％] and control group [(88.65 ± 2.41)％] (P ＜ 0.05),and there was significant difference between non-gastrointestinal dysfunction group and control group (P ＜ 0.05).Conclusion The expression of integrin α 4β 7 and L-selectin is decreased at the early stage of gastrointestinal dysfunction in critical childern,and integrin α 4 β 7 is decreased sharply.
