Correlation between serum macrophage migration inhibitory factor and regulated on activation normal T cell expressed and secreted cytokines in patients with chronic hepatitis B
10.3760/cma.j.issn.1673-4904.2013.04.001
- VernacularTitle:慢性乙型肝炎患者血清巨噬细胞移动抑制因子与调节激活正常T细胞表达和分泌的细胞因子的相关性分析
- Author:
Canhui XIAO
;
Ka ZHANG
;
Xingfei PAN
;
Feifei HUANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Chemotactic factors;
Macrophage migration inhibitory factor;
Regulated on activation normal T cell expressed and secreted cytokines
- From:
Chinese Journal of Postgraduates of Medicine
2013;(4):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels and correlation between macrophage migration inhibitory factor (MIF) and regulated on activation normal T cell expressed and secreted cytokines (RANTES) in patients with chronic hepatitis B (CHB).Methods Forty-four CHB patients (CHB group)and 30 healthy controls (control group) were enrolled in this study.The venous blood was collected and serum MIF and RANTES levels were detected by enzyme-linked immunosorbent assay.Correlation between MIF and RANTES was analyzed in CHB group.Results The serum MIF and RANTES levels in CHB group were significantly higher than those in control group [(8.48 ± 1.70) μ g/L vs.(1.99 ± 2.38) μ g/L,(3.94 ±2.38) μ g/L vs.(0.33 ± 0.15) μ g/L,P =0.000].There was no correlation between MIF level and RANTES level(r =0.212,P＞ 0.05).Conclusions The serum MIF and RANTES levels are significantly increased in patients with CHB,but there is no correlation.The participation pathogenesis way of CHB is different.
