Research progress experimental and detection method on pulmonary blast injury

VernacularTitle:肺冲击伤实验与检测方法研究进展
Author: Yong CHEN ; Haibin CHEN ; Yangyao OU ; Zhihuan YANG
Publication Type:Journal Article
Keywords: Shock wave; Lung injury; Experimental settings
From: International Journal of Biomedical Engineering 2013;(1):34-38
CountryChina
Language:Chinese
Abstract: Due to the air-filled alveoli and delicate vascular structure,the lung is the most easily damaged organ when human or animal is subjected to a shock wave.Primary pulmonary blast injury resulting from shock wave is an important cause of trauma not only in military conflicts but also in terrorism or accidents involving civilians.The physiological,pathological and biochemical changes after blast injury may lead to inflammatory response,cell apoptosis in the lung,boost the activation of cytokines including TNF-α,IL-6,IL-8 and IL-1β,and finally result in acute respiratory distress syndrome (ARDS).This paper presents the evolution and characteristics of pulmonary blast injury,and demonstrates four relevant experimental setups including biological shock tube,segmented shock wave generator,mini blast wave generator and laser-induced stress wave generator.Besides,this paper reviews the scoring system of pulmonary blast injury,pathological and biochemical measurement aiming to provide helpful reference to establish pulmonary blast injury models.