Relationship between heme oxygenase-1 and diabetes mellitus
10.3760/cma.j.issn.1673-4904.2013.13.012
- VernacularTitle:血红素氧化酶1与糖尿病的关联研究
- Author:
Xiaodong WANG
;
Xiurong RAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Heme oxygenase(decyclizing);
Prediabetic state
- From:
Chinese Journal of Postgraduates of Medicine
2013;(13):41-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of heme oxygenase-1 (HO-1) in type 2 diabetes mellitus (T2DM) as well as hidden diabetes mellitus (HDM) and explore its clinical significance.Methods A total of 384 suspected patients with T2DM having underwent oral glucose tolerance test were enrolled in this study:216 cases of patients were T2DM (T2DM group),and 168 cases of patients were HDM (HDM group).T2DM patients were divided into single-vessel lesion group(122 cases),double-vessel lesion group(54 cases),and more-vessel lesion group(40 cases).Another 60 healthy person were as control group.The intima-media thickness (IMT) of carotid was measured by ultrasonography.The level of serum HO-1 was detected with enzyme-linked immunosorbent assay.Results The serum level of HO-1 in control group,HDM group and T2DM group was (1.24 ± 0.53),(2.12 ± 0.84),(3.46 ± 1.23) μ g/L.The serum level of HO-1 in T2DM group was significantly higher than that in control group and HDM group (P ＜ 0.05),and in HDM group it was significantly higher than that in control group(P ＜ 0.05).There were significant differences in the serum level of HO-1 and IMT of carotid among single-vessel lesion group,double-vessel lesion group,and more-vessel lesion group [(2.94 ± 1.14),(3.72 ± 1.36),(4.64 ± 1.58) μg/L and (1.21 ±0.16),(1.44 ± 0.20),(1.62 ± 0.27) mm] (P ＜ 0.05).The serum level of HO-1 and IMT of carotid in double-vessel lesion group was higher than that in single-vessel lesion group,and in more-vessel lesion group it was higher than that in double-vessel lesion group and single-vessel lesion group (P＜ 0.05 or ＜ 0.01).The serum level of HO-1 was positively related with IMT of carotid (r =0.512,P ＜0.01).Conclusion The high-level expression of HO-1 is found in HDM and T2DM patients,which maybe play a key role in the early diagnosis of T2DM.
