Effect of atorvastatin on intima-media thickness of carotid and endothelial function in elderly patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2013.13.005
- VernacularTitle:阿托伐他汀对老年2型糖尿病患者颈动脉内膜-中层厚度及血管内皮功能的影响
- Author:
Jin ZHAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Carotid;
Atherosclerosis;
Endothelial function;
Atorvastatin
- From:
Chinese Journal of Postgraduates of Medicine
2013;(13):16-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of various dose of atorvastatin on intima-media thickness (IMT) of carotid and endothelial function in elderly patients with type 2 diabetes mellitus (T2DM).Methods One hundred and seventy-two elderly patients with T2DM were divided into three groups by random digits table method.Group A (63 cases) was treated with atorvastatin 10 mg/d,while group B (54 cases) was treated with atorvastatin 20 mg/d and group C (55 cases) was treated with atorvastatin 40 mg/d for 12 months.The serum levels of lipid,high-sensitive C reactive protein (hs-CRP),IMT of carotid and endothelial function were measured before and after treatment of 6,12 months.Results There were no significant differences in the levels of lipid,hs-CRP,IMT of carotid and endothelial function among three groups (P >0.05).The levels of total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol and hs-CRP were decreased and high density lipoprotein cholesterol was increased after treatment of 6,12 months in three groups (P < 0.05).The levels of TC,TG and hs-CRP after treatment of 12 months in group C were lower than those in group A and group B [(3.52 ± 0.55) mmol/L vs.(4.45 ± 0.71),(4.31 ± 0.75) mmol/L,(1.20 ±0.12) mmol/L vs.(1.64 ±0.18),(1.51 ±0.17) mmol/L,(4.22 ±0.28) mg/L vs.(5.34 ± 0.48),(5.02 ± 0.44) mg/L],and there were significant differences (P < 0.05).IMT of carotid,Crouse scores of plaque and the incidence of carotid plaque after treatment of 12 months in group C were lower than those before treatment [(0.84 ±0.07) mm vs.(1.07 ±0.10) mm,(4.03 ± 1.14) scores vs.(4.34 ± 1.18) scores,41.8%(23/55) vs.78.2%(43/55)],and there were significant differences (P < 0.05).The levels of endothelin and thromboxane B2 were markedly decreased in group C after treatment of 12 months [(68.48 ± 9.35) ng/L vs.(90.07 ± 10.19) ng/L,(80.08 ± 14.27) ng/L vs.(104.77 ± 12.36) ng/L],while the levels of nitric oxide and 6-Keto-PGF1α were increased [(72.28 ± 9.40)μ mol/L vs.(61.88 ± 10.01) μ mol/L,(72.39 ± 8.67) ng/L vs.(54.92 ± 10.78) ng/L],and there were significant differences(P<0.05).After treatment of 12 months,the levels of endothelium-dependent dilation were significantly increased in three groups (P < 0.05).The levels of endothelium-independent dilation in group B and group C were significantly increased after treatment of 12 months [(11.12 ± 1.00) % vs.(6.38 ± 0.49) %,(13.43 ± 1.11) %vs.(6.39 ± 0.52)%],and there were significant differences (P < 0.05).Conclusion Combined with hypoglycemic treatment,atorvastatin may delay the progress of carotid atherosclerosis and improve the endothelial function in elderly patients with T2DM.