Expression of Yes-associated protein in rectal cancer
10.3760/cma.j.issn.1673-4904.2013.05.004
- VernacularTitle:Yes相关蛋白在直肠癌中的表达及意义
- Author:
Zhishan CHEN
;
Changyi YANG
;
Liqing HONG
;
Zaiquan LIN
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Reverse transcriptase polymerase chain reaction;
Yes-associated protein;
Western bloting technology
- From:
Chinese Journal of Postgraduates of Medicine
2013;(5):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of Yes-associated protein (YAP) expression in rectal cancer and to explore the significance of YAP in rectal cancer.Methods Reverse transcriptase polymerase chain reaction(PT-PCR) and Western bloting technology were used to detect mRNA and protein expression of YAP in 30 patients with rectal cancer and 10 cases of normal rectal mucosa tissue.Results The expressions of mRNA and protein of YAP in rectal cancer were significantly higher than those in normal rectal mucosa tissue (73.2 ± 1 1.1 vs.10.4 ± 4.1,65.7 ± 9.5 vs.9.2 ± 4.3,P ＜ 0.05).Conclusion YAP high expression is related to the occurrence of rectal cancer.
