Correlation between serum adiponectin,leptin levels and motor functional outcome in patients with acute cerebral infarction
10.3760/cma.j.issn.1673-4904.2013.01.004
- VernacularTitle:急性脑梗死患者血清脂联素、瘦素水平与运动功能恢复的相关性研究
- Author:
Juntao GUO
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Adiponectin;
Leptin;
Fugl-Meyer score
- From:
Chinese Journal of Postgraduates of Medicine
2013;(1):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of serum adiponectin,leptin levels on motor functional outcome in the patients with acute cerebral infarction.Methods Forty-five patients with acute cerebral infarction and 30 healthy cases were selected as study group and control group.Motor functional outcome was evaluated by Fugl-Meyer score.Serum adiponectin and leptin levels were detected by enzyme linked immunosorbent assay.The correlation between serum adiponectin,leptin levels and motor functional outcome was assessed.Results Serum adiponectin level in control group [(13.78 ±4.25) mg/L] was higher than that in study group[(6.35 ± 3.18) mg/L],and there was significant difference between two groups (P ＜ 0.05).Serum leptin level in control group [(6.48 ± 1.26) μ g/L] was lower than that in study group [(20.35 ± 2.59) μg/L],and there was significant difference between two groups (P ＜0.05).There was significant difference in serum adiponectin and leptin levels among different Fugl-Meyer score in study group (P ＜ 0.05).Serum adiponectin level had positive correlation with Fugl-Meyer score (r =0.528,P ＜ 0.05).Serum leptin level had negative correlation with Fugl-Meyer score (r =-0.564,P＜ 0.05).There was negative correlation between serum adiponectin levels and serum leptin levels (r =-0.427,P ＜ 0.05).Conclusions Adiponectin and leptin is associated with pathogenesis of acute cerebral infarction.The correlation between serum adiponectin,leptin levels and motor functional outcome is close.
