The effect of Ulinastatin on coagulation function in patients with breast carcinoma during operation period
10.3760/cma.j.issn.1008-1372.2013.01.015
- VernacularTitle:乌司他丁对乳腺癌患者围术期凝血功能的影响
- Author:
Xiaoying XUE
;
Dianqing CAO
;
Guangping YANG
;
Jian MO
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors/pharmacology;
Breast neoplasms/surgery;
Intraoperative period;
Blood coagulation/drug effects
- From:
Journal of Chinese Physician
2013;(1):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective This trial was to observe the effect of Ulinastatin on coagulation functions in patients during operation period,and to investigate the protective mechanisms of Ulinastatin.Methods Forty patients were randomly divided into Ulinastatin group (Group U,n =20) and control group (Group C,n =20).Group U was infused intravenously ulinastatin 4000 U/kg (diluted with saline to 30 ml,20min losers) after anesthesia and before cutting skin,while Group C received the same volume of normal saline.All patients were phlebotomized 1 ml peripheral blood before administered (T0) and after 1 hour (T1),respectively.Coagulation activation time (SonACT),clot rate (CR) and platelet function (PF)were detected by sonoclot coagulation analyzer and platelet function analyzer.Results Compared with group C (controlled group),SonACT of Group U was prolonged significantly at T1 (P ＜ 0.05),and PF were increased at T1 (P ＜ 0.05) ; Compared with T0,SonACT and PF were increased at T1,respectively (P ＜ 0.01).Conclusions Ulinastatin can improve perioperative coagulation function and platelet function.It may reduce intraoperative micro-thrombosis syndrome and postoperative deep vein thrombosis.
