Protective effect of PNS in spinal cord hemisection injury and its cPLA2 related mechanism
- VernacularTitle:三七总皂苷对大鼠脊髓半横断损伤后神经保护作用及cPLA2相关机制
- Author:
Bin PI
;
Wei XIONG
;
Tian SHEN
;
Zhiyang ZHOU
;
Yang SUN
- Publication Type:Journal Article
- Keywords:
PNS;
Spinal cord hemisection injury;
cPLA2;
Rat
- From:
Journal of Chinese Physician
2012;(z2):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect and associated mechanism of PNS in spinal cord hemisection injury.Methods fifty-five adult SD rats were randomly divided into three groups,sham group(n =5),spinal cord injury group(n =25),PNS group(n =25).The rats were evaluated in behavioral test with BBB score,pathology and immunohistochemistry at 1 d,3d,7d,14d,21d after the procedures.Results Motor recovery was significantly better in PNS group than the spinal cord injury group at 3d,7d,14d and 21d.Nissl staining showed less neuron necrosis and more integrated neural cells in morphology.cPLA2 expression was inhabited in PNS group,and less number of positive cells were found in the group.Conclusion PNS can inhibit the expression of cPLA2 after spinal cord injury,which may be one of the mechanisms of its effect on promoting motor recovery.
