The expression of HDAC2 in lung of smoke cessation and smoking cessation rats
- VernacularTitle:香烟暴露与戒烟对大鼠肺组织组蛋白去乙酰化酶2的影响
- Author:
Yumei WANG
;
Fuyong QIAN
;
Peng LUO
- Publication Type:Journal Article
- Keywords:
Smoke exposure;
Smoking cessation;
HDAC2
- From:
Journal of Chinese Physician
2012;(z2):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of HDAC2 in lung of smoke cessation and smoking cessation rats,Methods Forty SD rats were divided into five groups randomly:normal control group (group A),1-month smoking group (group B,),2-month smoking group (group C),1-month smokingcessation group(group D),2-month smoking-cessation group(group E).Group B rats were exposured to cigarettes for 1 month,C,D,E were exposured to cigarettes for 2 months.At 1 month,group B were sacrificed,at 2 month,group C were sacrificed,group D was smoking cessation for 1 month and group E for 2 months.Pathomorphological changes of the small airway were analyzed,and then study the HDAC2 in rats'lung tissue.Results Compared with group A,the levels of HDAC2 in group B,group C,group D,group E were decreased (P ＜ 0.01),but smoking groups levels were lower than smoking-cessation groups.In smoking groups,group C was lower than group B.In smoking-cessation groups,group D was lower than group E.Conclusion It shows that the levels of HDAC2 in rats' lung tissue decrease after smoking exposure.It can recrease after quitting,but still cant back to normal.
