The level and its clinical significance of microRNA-21 in cerebrospinal fluid of glioma patients
10.3760/cma.j.issn.1673-4904.2013.02.002
- VernacularTitle:微RNA-21在神经胶质瘤患者脑脊液中的水平及意义
- Author:
Xin CHEN
;
Taifeng PAN
;
Lintao WANG
;
Binjie ZHAO
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Glioma;
Cerebrospinal fluid
- From:
Chinese Journal of Postgraduates of Medicine
2013;(2):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the level and its clinical significance of microRNA-21 (miR-21) in cerebrospinal fluid of glioma patients.Methods The level of miR-21 in cerebrospinal fluid were measured by real-time RT-PCR in 40 patients with glioma (glioma group) and 40 normal controls(control group).The relationship between miR-21 and pathological grade were analyzed.Results The level of miR-21 in glioma group was significantly higher than that in control group (0.70 + 0.12 vs.0.43 + 0.09,t =11.3840,P ＜ 0.01).The level of miR-21 in glioma group with Ⅱ,Ⅲ and Ⅳ pathological grade was 0.66 +0.11,0.71 + 0.12,0.74 ± 0.13,there was no significant difference (F =1.5083,P =0.2345).Conclusions The level of miR-21 in cerebrospinal fluid of glioma patients elevates significantly.It may participate in the occurrence and development of glioma.
