Expression and clinical significance of serum vascular endothelial growth factor in children with Wilms tumor
10.3760/cma.j.issn.1673-4904.2013.09.012
- VernacularTitle:血清血管内皮生长因子在儿童肾母细胞瘤中的表达及临床意义
- Author:
Qiuxia FAN
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factors;
Wilms tumor;
Child;
Serum
- From:
Chinese Journal of Postgraduates of Medicine
2013;(9):36-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum vascular endothelial growth factor (VEGF) in children with Wilms tumor,and clarify the effect of VEGF in the invasion and progression of Wilms tumor.Methods Thirty children with Wilms tumor who underwent surgical treatment were retrospectively analyzed as Wilms tumor group,the control group was 30 children who underwent treatment by cold and fever symptoms.The serum VEGF levels of 2 groups were detected by enzyme-linked immunosorbent assay.Results The serum VEGF level of Wilms tumor group was significantly higher than that of control group [(567.90 ± 189.30) ng/L vs.(55.46 ± 18.49) ng/L,t =14.757,P ＜0.05].The expression of serum VEGF was closely related to NWTS stage,prognosis tissue type and lymph node metastasis (P ＜ 0.01).The expressions of serum VEGF in the NWTS Ⅲ-Ⅳ stage,lymph node metastasis and poor prognosis tissue type Wilms tumor were significantly higher than those of NWTS Ⅰ-Ⅱ stage,without lymph node metastasis,good prognosis tissue type Wilms tumor (P＜ 0.01).Conclusions The expression of serum VEGF is high in children with Wilms tumor,the serum VEGF level is closely related to NWTS stage,prognosis tissue type and lymph node metastasis.The high expression of serum VEGF shows the invasion,progression and poor prognosis in children with Wilms tumor.
