The correlation research between tumor necrosis factor-α,osteopontin,interleukin-6 and psoriasis vulgaris
10.3760/cma.j.issn.1673-4904.2013.09.002
- VernacularTitle:肿瘤坏死因子-α、骨桥蛋白、白细胞介素-6与寻常型银屑病发病的相关性研究
- Author:
Changwei CAI
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Tumor necrosis factor-alpha;
Osteopontin;
Interleukin-6
- From:
Chinese Journal of Postgraduates of Medicine
2013;(9):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between tumor necrosis factor (TNF)-α,osteopontin (OPN),interleukin (IL)-6 and psoriasis vulgaris.Methods Participants included 90 patients with psoriasis vulgaris,active period of 30 cases,stationary period of 30 cases,retrograde period of 30 cases.At the same time,30 healthy check-up health person were as controls.Early morning all observation objects were extracted fasting venous blood 5 ml,the serum levels of TNF-α,OPN and IL-6 were detected by enzyme-labeled immunoassay and compared.Results The serum levels of TNF-α,OPN and IL-6 in active period,stationary period and retrograde period patients [(28.3 ± 11.2) ng/L,(68.3 ±4.2) μg/L,(18.3 ±1.2) ng/L; (19.8 ± 10.5) ng/L,(52.8 ±3.5) μg/L,(12.8 ± 1.5) ng/L; (10.4 ± 11.6) ng/L,(46.4 ±3.6)μ g/L,(9.4 ± 1.6) ng/L] were obviously higher than those in controls [(6.6 ± 7.2) ng/L,(32.6 ± 3.2) μ g/L,(7.6 ± 1.2) ng/L] (P ＜ 0.05),and these levels in active period patients were higher than those in stationary period and retrograde period patients (P ＜ 0.05),and these levels in stationary period patients were higher than those in retrograde period patients (P ＜ 0.05).Conclusions There is a close correlation between serum levels of TNF-α,OPN and IL-6 and the occurrence of psoriasis vulgaris.And along with the patients from active period,stationary period to retrograde period occurrence,the levels can change,but the specific mechanism is still unclear,which need further investigation.
