Research progress of the pathophysiological role of receptor activity modifying proteins

VernacularTitle:受体活性修饰蛋白病理生理作用的研究进展
Author: Zhiliang ZHAO ; Gang ZHANG ; Yinghui TAN
Publication Type:Journal Article
Keywords: Receptor activity modifying proteins; Calcitonin gene-related peptide; Calcitonin receptor; Calcitonin receptor-like receptor; G protein coupled receptors
From: International Journal of Biomedical Engineering 2013;(1):51-55
CountryChina
Language:Chinese
Abstract: Receptor activity modifying proteins (RAMPs) is a kind protein with transmembrane functionality.RAMPs can interact with TypeⅡ G protein coupled receptors (GPCRs) such as calcitonin gene-related peptide receptor (CGRPR),calcitonin receptor (CTR) and calcitonin receptor-like receptor (CRLR),to form a stable heterodimer expression on the cell membrane.Different RAMPs can combine with CRLR or CTR to produce different receptor phenotypes with ligand-specific affinity and thus can decide biological effect of the receptors.In addition,RAMPs can also interact with other GPCRs,which promise broader application in function regulation of G-proteincoupled receptor of RAMPs'.RAMPs' regulation of GPCRs depends on its molecular basis.Our studies of RAMPs provides a new perspective to further researches on GPCRs functionality and CGRP signal transduction.