Research progress of injected hydrogel in the treatment of myocardial infarction
10.3760/cma.j.issn.1673-4181.2013.01.014
- VernacularTitle:可注射水凝胶在心肌梗死治疗中的研究进展
- Author:
Li WANG
;
Zhiming ZHU
- Publication Type:Journal Article
- Keywords:
Injectable hydrogels;
Stem cells;
Cell replacement therapy;
Ventricular remodeling;
Myocardial infarction
- From:
International Journal of Biomedical Engineering
2013;(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Due to myocardial necrosis and fibrous scar formation after acute myocardial infarction,patient's ventricular remodeling and cardiac function is reduced,which will cause serious impact on the long-term prognosis of patients with myocardial infarction.As new biological substitute materials,the hydrogels are superior in hydrophilicity and biocompatibility and have been widely used in the research of myocardial infarction's treatment.The hydrogels can be used alone or served as a promising cell/drug delivery vehicle.Many reports show that intramyocardial injection of hydrogels attached with stem cells and drugs can prevent left ventricle (LV) wall thinning,increase arteriole and capillary density,raise restoration ratio of implanted stem cells,facilitate controlled release of bioactive drugs,limit post-ischemic remodeling and preserve LV function in a certain extent.This article reviews injectable hydrogels research progress in the treatment of myocardial infarction.
