Clinical Significance of Galectin-3 Expression in Bladder Cancer
- VernacularTitle:Galectin-3在膀胱癌中的表达及临床意义
- Author:
Qiguang CHEN
;
Qi YANG
;
Zhe ZHANG
;
Xiuyue YU
;
Guangyi SHAN
;
Chuize KONG
- Publication Type:Journal Article
- Keywords:
Galectin-3;
bladder cancer;
pathological grade;
clinical stage;
immunohistochemistry
- From:
Journal of China Medical University
2010;(9):755-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the galectin-3 expression in bladder cancer and explore the relationship between the galectin-3 expres-sion and the clinicalpathological characteristics of bladder cancer.Methods Immunohistochemical streptavidin-peroxidase（S-P）method was employed to examine the expression of galectin-3 in 45 bladder cancer tissues and 6 normal bladder tissues.The relationship between galectin-3 expression and the clinicopathological parameters was analyzed in bladder cancers.Results The positive rate of galectin-3 ex-pression in bladder cancer was 62.2%,significantly higher than that in 6 normal bladder tissues（P 〈 0.05）.The positive rates of galectin-3 expression in primary cases and recurrent cases were 60% and 70% respectively without significant difference（P 〉 0.05）.The up-regulated expression of galectin-3 was positively correlated with the pathological degree and clinical stage of bladder cancer（P 〈 0.05）.Conclusion Galectin-3 expression is up-regulated in bladder cancer and its increased expression is useful for diagnosis of bladder cancer.Additionally,it could be used as an important index to evaluate the pathological degree and clinical stage of bladder cancer.
