Expression of Cyclooxygenase-2 in Helicobacter pylori-infected Gastric Cancer and Its Effect on the Invasion and Metastasis of Gastric Cancer
- VernacularTitle:幽门螺杆菌感染胃癌组织中环氧合酶2的表达及其对胃癌侵袭和转移能力的影响
- Author:
Dongxu CAO
;
Jing CHI
- Publication Type:Journal Article
- Keywords:
Helicobacterpylori;
gastric cancer;
cyclooxygenase-2;
immunohistochemistry
- From:
Journal of China Medical University
2010;(9):767-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of cyclooxygenase-2（COX-2）on the invasion and metastasis of gastric cancer with Helicobacter pylori（H.pylori）infection.Methods A total of 60 gastric cancer specimens were included in this study.H.pylori infection was deter-mined by improved Giemsa method and the expression of COX-2 was examined by immunohistochemistry.The correlation between H.pylori infection and the clinical pathological features of gastric cancer was analyzed.Results H.pylori infection was detectable in 36 of 60 cases（60.0%）,and correlated with the staging（χ2=28.040,P =0.000）and lymph node metastasis（χ2=25.482,P =0.000）,but not with the age,sex of patients or histological types.H.pylori infection also significantly linked to the expression of COX-2（χ2=24.326,P 〈 0.001）.Con-clusion H.pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of COX-2.
