Relationship between the Expression of Ki67 and Mitosis Karyorrhexis Index in Ganglioneuroblastoma
- VernacularTitle:有丝分裂核碎裂指数在节细胞神经母细胞瘤预后评价中的意义及其与Ki67表达的相关性
- Author:
Zhe WANG
;
Tie MA
;
Xianghong YANG
;
Keren ZHANG
- Publication Type:Journal Article
- Keywords:
ganglioneuroblastoma;
proliferating cell antigen;
prognosis;
mitosis karyorrhexis index
- From:
Journal of China Medical University
2010;(6):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of Ki67 and mitosis karyorrhexis index（MKI）in ganglioneuroblastoma（GNB）.Methods Clinical materials and histology slides from 28 patients with GNB were reviewed.MKI was counted under microscope and the expression of Ki67 protein in GNB was evaluated by immuohistochemical technique.The follow-up data were also collected and statistically analyzed.Results There were 15 patients with favourite prognosis（favourite subgroup,FS） and 13 patients with poor prognosis（unfavourite subgroup,US）.The survival time of GNB patient in FS was significantly longer than that in US（P 0.05）.The survival time is related to pathology classification（P 0.05）.MKI was correlated with advanced clinical stage,pathology classification and survival time（P 0.001）.No significant difference in Ki67 expression was found between low and high MKI patients.Conclusion MKI might be a reliable prognostic parameter for making diagnosis and evaluating prognosis of GNB.Detection of Ki67 expression might be not useful for evaluating the prognosis of GNB.
