Effect of Peroxisome Proliferator-activated Receptor δ Activation on the Expression of Tenascin-C in Infarcted Myocardium
- VernacularTitle:激活过氧化物酶体增殖物激活受体-δ对梗死心肌腱糖蛋白表达的影响
- Author:
Dachun YANG
;
Shuangtao MA
;
Xiaohua SU
;
Xiuchuan LI
;
Jihong ZHANG
;
Bing TANG
;
De LI
;
Yongjian YANG
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-acfivated receptors δ;
myoearclial infarction;
myocardial remodeling;
tenascin-C
- From:
Journal of China Medical University
2010;(9):730-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of the present study was to investigate the effect of peroxisome proliferator-activated receptors δ（PPAR δ）activation with dietary GW610742X on the expression of tenascin-C in the infarcted and remodeling myocardium.Methods Sixty male Wistar rats were divided into four groups,including control group,sham group,myocardial infarction（MI） group,and MI＋GW610742X（GW）group.The left coronary artery was ligated to establish the MI model.PPAR δ activator GW610742X（100mg/kg/d）was administrated into the rats of GW group.At 3 months after procedure,the expression and distribution of tenascin-C in left ventricular free wall from each group were examined by Western blotting and immunofluorescence,respectively.Results After 3 months following procedure,there were obvious necrosis and fibrosis in left ventricular free wall from MI group.The expression of tenascin-C in MI and GW group was significantly higher than those in control and sham group（P 〈 0.01）.Moreover,tenascin-C expression in GW group was remarkably decreased compared to MI group（P 〈 0.05）.Additionally,tenascin-C expression in sham group was similar to that in control group（P 〉 0.05）.Conclusion The tenascin-C is upregulated in infarcted myocardium during the remodeling process,which can be significantly attenuated by PPAR δ activation.
