Association Between HLA-A, HLA-B Alleles and Alopecia Areata
- VernacularTitle:辽宁地区斑秃患者与HLA-A、HLA—B等位基因相关性研究
- Author:
Haiyan JIANG
;
Ning ZHAI
;
Jianping LI
;
Yang CHEN
;
Yuxiao QIN
;
Yue ZHANG
;
Yanfeng CHENG
;
Fan YANG
;
Xiuping HAN
- Publication Type:Journal Article
- Keywords:
alopecia areata;
HLA-A;
HLA-B alleles
- From:
Journal of China Medical University
2010;(9):758-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between HLA-A and B alleles and alopecia areata.Methods HLA-A and-B alleles were studied by LABTypeTM SSO in 44 patients with alopecia areata and 200 healthy controls.Results The frequencies of HLA-A＊11（χ2=6.08,P 〈 0.05）,HLA-B＊13（χ2=29.80,P 〈 0.01）,HLA-B＊40（χ2=8.04,P 〈 0.01）,HLA-B＊46（χ2=5.86,P 〈 0.05）and HLA-B＊51（χ2=8.82,P 〈 0.01）alleles were significantly increased in alopecia areata patients compared with the control.Conclusion HLA-A＊11,HLA-B＊13,HLA-B＊40,HLA-B＊46 and HLA-B＊51 might be the susceptible alleles of the patients with alopecia areata.
