The Preventive Effect of Sodium Ferulate on Contrast-Induced Renal Injury in Chronic Renal Insufficiency Patients
- VernacularTitle:阿魏酸钠对慢性肾功能不全患者造影剂肾脏损伤的预防作用及机制
- Author:
Guangping SUN
;
Rui YU
;
Detian LI
- Publication Type:Journal Article
- Keywords:
contrast medium;
chronic renal insufficiency;
sodium ferulate
- From:
Journal of China Medical University
2010;(9):761-763
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether sodium ferulate（SF）can prevent contrast-induced renal injury in chronic renal insufficiency patients and its possible mechanism.Methods Eighty-six patients with chronic renal insufficiency,whose serum creatinine（Scr）levels ranged from 132 μmol/L to 358 μmol/L were randomly divided into control group（saline 100 ml iv drip）and SF treatment group（treatment group,saline 100 ml ＋ 0.3 g SF iv drop）based on sufficient hydration.Patients were treated with the above-mentioned protocols at 3 h be-fore the administration of contrast medium and in the following 3 days,Scr,plasma malondialdehyde（MDA）and urine nitric oxide（NO）were measured before angiography and on the third day after angiography.Results The incidence rate of contrast-induced nephropathy（CIN）in control group was significantly higher than that in treatment group（P 〈 0.05）.The contrast medium increased Scr levels and plasma MDA,and decreased urine NO excretion,while SF treatment attenuated the above changes（P 〈 0.05）.Conclusion The preventive effect of SF on con-trast-induced renal injury might be associated with its suppressive effect on endothelin,increasing renal production of NO and anti-oxydation.
