Serum Levels and Clinical Significance of Interferon-λ1 in Systemic Lupus Erythematosus Patients

VernacularTitle:系统性红斑狼疮患者血清λ1干扰素的测定及临床意义
Author: Fang FANG ; Weiguo XIAO
Publication Type:Journal Article
Keywords: systemic lupus erythematosus; interferon-lambda 1
From: Journal of China Medical University 2010;(2):153-155
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of serum interferon-λ1(IFN-λ1) levels in patients with systemic lupus erythematosus(SLE).Methods ELBA was used to evaluate the serum level of interferon-λ1 in 60 patients with SLE and 20 healthy individuals as normal control.SPSS10.0 statistic software was employed to investigate the relation between the serum IFN-λ1 level,the laboratory index and SLE disease activity index(SLEDAI).Results The serum IFN-λ1 level in SLE patients(74.2±16.1 pg/ml) was higher than that of the normal controls(70.4±12.6 pg/ml,P=0.339).The serum IFN-λ1 level in SLE patients with leucopenia(80.1±18.1 pg/ml) was higher than those of the normal control(P=0.052) and the SLE patients without leucopenia(70.6±13.7 pg/ml,P=0.024).The serum IFN-λ1 level was not correlated with SLEDAI,complements C3,C4,24-hour-proteinuria.Conclusion IFN-λ1 may be involved in the pathogenesis of leukopenia in SLE and it has not been proved that its level was correlated with the disease activity.