Expression and Significance of Fascin and Ki-67 Proteins in Bladder Carcinoma
- VernacularTitle:fascin及Ki-67蛋白在膀胱癌中的表达及意义
- Author:
Xuelei CHEN
;
Bingxun LI
;
Hailin SHEN
;
Qiguang CHEN
;
Zhe ZHANG
;
Jianbin BI
;
Chuize KONG
- Publication Type:Journal Article
- Keywords:
bladder carcinoma;
fascin;
Ki-67;
immunohistochemistry
- From:
Journal of China Medical University
2010;(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunoreactivity of fascin and Ki-67 proteins in bladder carcinoma and the correlation between their expression and the pathological features.Methods The immunohistochemistry of fascin and Ki-67 proteins were detected in 111 cases of bladder carcinoma and 42 cases of normal bladder tissues.The correlation between their expression and the pathological features were analyzed statistically.Results There was no expression of fascin and Ki-67 in normal bladder tissues.The immunoreactivities of fascin and Ki67 were detected respectively in 94 and 92 of 111 bladder carcinomas.The immunoreactivity of fascin was correlated with TNM staging and the size of the tumor(P<0.05),and had no correlation with age,gender and pathological classification(P>0.05).The expression of fascin was positively correlated with the expression of Ki-67 in bladder carcinoma(P<0.01).Conclusion Fasicn and Ki-67 were expressed in bladder carcinoma.The combined detection of fascin and Ki-67 expression might be helpful to assess the prognosis of bladder carcinoma.Targeting the fascin and Ki-67 pathway could be a novel therapeutic strategy of bladder carcinoma.
