Expression and Clinical Significance of Twist Protein in Non-small Cell Lung Carcinoma
- VernacularTitle:Twist蛋白在非小细胞肺癌中的表达及临床意义
- Author:
Hong SHU
;
Honglan ZHANG
;
Xiaodong ZHAO
;
Weiguo JIANG
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
Twist protein;
immunohistochemistry;
prognosis
- From:
Journal of China Medical University
2010;(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance and the expression of Twist protein in non-small cell lung cancer(NSCLC).Methods The expression of Twist protein was examined in formalin-fixed paraffin-embedded tissue samples of 61 NSCLC by S-P immunohistochemical method.Results The expression level of Twist in NSCLC was significantly higher than that of normal lung tissue;the positive expression of Twist protein was related to the histotype,clinical stage and lymph node metastasis;the expression level of Twist protein in the cases whose survival time was less than 4 years was significantly higher than that in the cases whose survival time more than 4 years;the Cox analysis revealed that smoking and lymph node metastasis were the noticeable affective factors on the death of the NSCLC patients after surgery.Conclusion s Twist gene played an important role in the genesis and development of NSCLC,and was related to the prognosis.
