Micronucleus Test of a New Machinable Bioactive Glass-ceramic Material
- VernacularTitle:一种新型可切削生物活性玻璃陶瓷的微核实验
- Author:
Yuquan HAO
;
Xiulin YAN
;
Yixiao ZHANG
;
Xuesong HAN
;
Minda LIU
;
Hongjun AI
- Publication Type:Journal Article
- Keywords:
glass-ceramic;
micronucleus test;
mutagenicity
- From:
Journal of China Medical University
2010;(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the potential mutagenicity of a new machinable bioactive glass-ceramic material.Methods Thirty N1H mouse inbred line (female:male =1:1) were divided to three groups at random (n =10),including glass-ceramic groups (oral administration of 5 g/kg glass-ceramic powder and arabic gum),negative control group (arabic gum in equal volume),and positive control group (oral administration of 40 mg/kg cyclophosphamide).The mice orally intook the equivalent liquor and were sacrificed with bone marrow cells abstracted 24 hours later.The micronucleated cells were counted in 1 000 polychromatic erythrocytes (PCE) per mouse,then the rate of the micronucleus in every group was measured.Results The rate of the micronucleus in glass-ceramic group,negative control group and positive control group was 1.31±0.53‰, 1.32±0.62‰ and 29.20±0.74‰ respectively.There was no significant difference in the rate of the micronucleus between the experimental and negative groups (P＞0.05),while a significant difference in the rate of the micronucleus was observed between experimental and positive groups (P＜0.01).Conclusion The new machinable bioactive glass-ceramic materials couldn't increase the micronucleus rate of mouse bone marrow cells.
