Effect of Telmisartan on Renal Expression of Adiponectin in Insulin-resistant Rats
- VernacularTitle:替米沙坦对胰岛素抵抗大鼠肾脏脂联素表达的影响
- Author:
Shupo LIN
;
Jie LIN
;
Jin SHI
- Publication Type:Journal Article
- Keywords:
insulin resistance;
adiponectin;
telmisarlan
- From:
Journal of China Medical University
2009;(10):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of telmiaartan on renal expression of adiponectin (APN) in insulin resistance rats. Methods Insulin resistance rat model was induced by long-term high-fat feeding and was assessed by euglycemic-hyperinsulinemia clamp technique. The morphological changes of the kidney lissue were observed by the light and electronic microscopy.Glomerular APN mRNA ex-pression and protein synthesis were evaluated by the reveree transcription polymerase chain reaction and immunohistochemical staining re-spectively. Results Both APN mRNA and APN protein were lower in insulin resistance rats than those in control rats (P < 0.05). More-over, the main features of the renal parenchyma were observed in insulin resistance rats. The expression levels of APN mRNA and APN pro-tein were increased after the treatment with lelmisartan (P <0.05). The renal damage was significantly reduced as well. Conclusion The up-regulation of APN expression induced by telmisartan might prevent the renal damage of insulin resistance.
