Effect of PNCG on the Expression of CLA+T Cell Derived Cytokines in Atopic Dermatitis
- VernacularTitle:卡介菌多糖核酸对特应性皮炎外周血CLA~+T细胞表达不同细胞因子的影响
- Author:
Li ZIIANG
;
Ruiqun QI
;
Yan SUN
;
Guohong CHEN
;
Hongwei REN
;
Hongduo CHEN
;
Xinghua GAO
- Publication Type:Journal Article
- Keywords:
atopic dermatitis;
polysaccharide and nucleoside extract from bacille Calmett- Guerin;
cutaneous lymphocyte-associated anti-gen;
cytokines
- From:
Journal of China Medical University
2009;(10):764-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of polysaccharide and nucleoside extract from bacille Calmett-Gueiin (PNCG) on the frequency of peripheral cutaneous lymphocyte-associated antigen positive (CLA~+) T lymphocyte derived lymphokines in atopic dermatitis (AD) and to explore their associations with the disease severity. Methods A randomized,double blind and placebo cross-over control method was used to treat the AD patients. Before and after the treatment,flow cytometry was used to measure the frequencies of IL-4,IL-5, IFN-γ,TNFα positive CLA~+T cells. Disease severity was evaluated by atopic dermatitis area and severity index score (ADASIS). Results After the PNCG treatment,the frequency of IL-5~+ CLA~+T cell decreased significantly,while IFN-γ increased,compared with the placebo con-trol group. PNCG could improve the ADASIS. Conclusion PNCG may treat AD through restoring the immune balance of CLA~+T cells.
