Expression and Relationship of OPN and MMP-9 in Epithelial Ovarian Carcinoma
- VernacularTitle:骨桥蛋白和基质金属蛋白酶9在上皮性卵巢癌中的表达及二者相关性
- Author:
Yu DAI
;
Yisheng JIAO
;
Yonglai WANG
- Publication Type:Journal Article
- Keywords:
osteopontin;
matrixmetallopoteinase-9;
epithelial ovarian carcinoma;
immunohistochemistiy
- From:
Journal of China Medical University
2009;(10):775-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and relationship of osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) in epithe-lial ovarian carcinoma. Methods Immunohistochemical staining S-P methods was used to detect the expression of OPN and MMP-9 in the samples of 60 epithelial ovarian carcinoma,20 benign ovarian tumor,20 borderline ovarian tumor and 10 normal ovarian tissue. Results The expression level of OPN and MMP-9 in epithelial ovarian carcinoma(109.86±21.51) were significantly higher than those in borderline ovarian tumor(45.81±8.93),benign ovarian tumor(11.86±3.01) and normal ovarian tissue(5.32±2.74). The expression level of OPN and MMP-9 related to the tumor grading,tumor stage and lymph node metastasis,while had no relationship with histological grading. There was significant positive correlation between OPN and MMP-9 in epithelial ovarian carcinoma (r = 0.80,P < 0.05). Conclusion The increased expression of OPN and MMP-9 may play an important role in the process of carcinogenesis, progression and differentiation of epithelial ovari-an carcinoma. OPN and MMP-9 may be a useful targets for treatment of ovarian carcinoma.
