Effects of Gastrin and Somatostatin in Diabetic Gastroparesis
- VernacularTitle:胃泌素和生长抑素在糖尿病胃轻瘫中作用的研究
- Author:
Bo WU
;
Qiang DU
;
Changqing ZHENG
;
Qian LI
- Publication Type:Journal Article
- Keywords:
diabetic gastroparesis;
gastrin;
somatostatin;
reversed transcript polymerase chain reaction
- From:
Journal of China Medical University
2009;(10):783-785
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of gastrin(GAS) and somatostatin(SS) in diabetic gastroparesis (DGP). Methods Totally 103 patients were divided into normal control group (n =17),simple gastroparesis(GP) group (n =30),simple diabetes mellitus(DM) group (n =23) and diabetes mellitus complicated with gastroparesis (DGP) group (n =33). Radioimmunity and RT-PCR were performed to detect the serum GAS and SS levels and the mRNA expression in the gastric mucosa tissue of 4 groups. Results There were significant differences in the serum levels and protein expression of GAS and SS between simple gastroparesis group,simple diabetes mellitus group, DGP group and the normal control group(P< 0.05). The differences between DGP group and normal control group was the most significant (P< 0.01), the differences between DGP group and the simple gastroparesis group or simple diabetes mellitus group were significant (P< 0.05). Contusion The increase of GAS and decrease of SS may play an important role in the occurrence and development of DGP.
