Changes of Vα24~+Vβ11~+, CD161~+Vα24~+NKT Cells in Peripheral Blood of Systemic Lupus Erythematosus Patient
- VernacularTitle:系统性红斑狼疮患者外周血中Vα24~+Vβ11~+、CD161~+Vα24~+NKT细胞变化及其相关指标的研究
- Author:
Xueman YU
;
Xiaofei WANG
;
Xiaoli ZHANG
;
Juanjuan CHEN
- Publication Type:Journal Article
- Keywords:
natural killer T cell;
systemic lupus erythematosus;
flow cytometry
- From:
Journal of China Medical University
2009;(10):767-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of the amount and function of Vα24~+Vβ11~+,CD161~+Vα24~+NKT cells in the peripheral blood of systemic lupus erythematosus (SLE) patients. Methods The amount of Vα24~+Vβ~+,CD16~+Va24~+NKT cells in the peripheral blood of 30 SLE cases and 30 healthy persons were detected by flow cytometry. Results Vα24~+Vβ11~+,CD161~+Vα24~+NKT cells in the peripheral blood of SLE patients were significantly lower than that of normal control (P < 0.05). Vα24~+Vβll~+ and CD161~+Va24~+NKT cells in the pe-ripheral blood of SLE patients positively correlated with the level of the complement (C3,C4) and negatively correlated with SLE disease ac-tivity index (SLEDIA) and ESR. Conclusion Activated NKT cells decreased in the peripheral blood of SLE patients. Vα24~+Vβ11~+ and CD161~+Vα24~+NKT cells might be involved in the pathogenesis and development of SLE.
