Changes and significance of serum total bilirubin,gamma glutamyltransferase in patients with type 2 diabetes
10.3760/cma.j.issn.1673-4904.2013.04.011
- VernacularTitle:血清总胆红素、γ-谷氨酰转移酶在2型糖尿病患者中的变化及意义
- Author:
Wenjia WU
;
Xiaohong JIANG
;
Haiyan JIANG
;
Fei HUA
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Bilirubin;
Gamma-glutamyltransferase;
Oxidative stress
- From:
Chinese Journal of Postgraduates of Medicine
2013;(4):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of serum total bilirubin (TBil) and gamma glutamyltransferase (GGT) in patients with type 2 diabetes newly diagnosed without complications and explore their relationship with vascular complications of type 2 diabetes.Methods The levels of serum TBil and GGT were determined by automatic biochemical analyzer in 42 healthy person (control group),64patients with type 2 diabetes without complications (diabetes without complications group) and 81 patients with type 2 diabetes with vascular complications (diabetes with complications group).Results The levels of serum TBil and GGT were (7.89 ± 4.81) μ mol/L and (29.81 ± 14.97) U/L in diabetes with complications group.The level of serum TBil was (10.42 ± 3.55) μ mol/L in control group.The levels of serum TBil and GGT were (11.30 ± 4.16) μ mol/L and (47.00 ± 38.57) U/L in diabetes without complications group.The level of serum TBil in diabetes with complications group was lower than that in control group and diabetes without complications group (P ＜ 0.05).The level of serum GGT in diabetes with complications group was lower than that in diabetes without complications group (P ＜ 0.05).Pearson correlation analysis showed that 24-hour urinary protein excretion,urinary albumin creatinine ratio had negative correlation with serum TBil (P ＜0.05).Logistic regression analysis showed that GGT was the protective factor of diabetic vascular complications (OR =0.965).Conclusion The levels of serum TBil and GGT may be associated with the occurrence and development of vascular lesions in patients with type 2 diabetes.
