Anti-N-methyl-D-aspartate receptor encephalitis in children
10.3760/cma.j.issn.1673-4408.2013.02.022
- VernacularTitle:儿童抗N-甲基-D-天冬氨酸受体脑炎
- Author:
Chen CHEN
- Publication Type:Journal Article
- Keywords:
Anti-N-methyl-D-aspartate receptor encephalitis;
Autoimmune;
Children;
Treatment
- From:
International Journal of Pediatrics
2013;(2):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune syndrome of central nervous system.The main clinical manifestations include psychiatric symptoms,movement disorders and seizures.It is often misdiagnosed as viral encephalitis.Tumors,especially the ovarian teratoma,play an important role in the disease.The prevalence in children is beyond imagination.Anti-NMDAR antibodies are specific diagnostic tests.Immune suppression is the main treatment.The first-line treatments include corticosteroids,intravenous immunoglobulin,and plasmapheresis.The second-line treatments include biological agents and cytotoxic drugs.Early diagnosis and treatment are essential for neurologic recovery.Overall prognosis is good.
