Progress in non-renal derived adult stem cell therapy for kidney disease
10.3760/cma.j.issn.1673-4408.2013.02.024
- VernacularTitle:非肾脏来源的成体干细胞移植治疗肾脏疾病的进展
- Author:
Yuhong TAO
;
Yu WANG
;
Yamei WANG
- Publication Type:Journal Article
- Keywords:
Stem cell transplantation;
Hematopietic stem cells;
Mesenchymal stem cells;
Induced pluripotent stem cells;
Kidney disease
- From:
International Journal of Pediatrics
2013;(2):187-190
- CountryChina
- Language:Chinese
-
Abstract:
This review focuses on the current literatures on the therapeutic potential of non-renal derived adult stem cell transplantation for kidney disease.Although the therapeutic mechanism remains debatable,some reports suggest that hematopoietic stem cell transplantation holds potential for treatment of renal diseases such as renal ischemia reperfusion injury,IgA nephropathy and lupus nephritis.Mesenchymal stem cell(MSC) are capable of homing to injured kidney and contribute to activate intrinsic kidney cells,promote angiogenesis,inhibit oxidative stress and reduce apoptosis,inflammation and renal fibrosis.These renoprotective effects are likely mediated by paracrine/autocrine mechanism via cytokine and microvesicles from MSC.Pluripotent stem cells may be induced from fibroblast,mesangial cells,renal tubular epithelial cell and urine epithelial cell.Induced pluripotent stem cell(iPSC) can differentiate into renal lineage cells.The derivation of kidney disease-specific iPSC opens new avenues for the resolution to limited donor availability in kidney transplantation and for treating kidney diseases such as diabetic nephropathy and autosomal dominant polycystic kidney disease.
