The relationship between hypertensive disorder complicating pregnancy and serum free estriol and its impact on pregnancy outcomes
10.3760/cma.j.issn.1008-6706.2013.01.005
- VernacularTitle:妊娠期高血压疾病与血清游离雌三醇的相关性及其对妊娠结局的影响
- Author:
Lihua FU
;
Yujie GAN
;
Yanming GUAN
;
Xihuan HUANG
;
Jinwen GAO
;
Fengping JIAN
- Publication Type:Journal Article
- Keywords:
Pregnancy complications,cardiovascular;
Estriol;
Pregnancy outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the relationship between hypertensive disorder complicating pregnancy and serum free estriol 3 (FE3) and explore its impact on pregnancy outcome.Methods Clinical data of 117 hypertensive disorder complicating pregnancy and 165 normal pregnant women were retrospectivly analyzed.Chemiluminescence immunoassay determination of maternal serum FE3 also had been conducted.Then analyzing the correlation between hypertensive disorder complicating pregnancy and FE3 and its impact on pregnancy outcomes.Results LDL cholesterol and the level of creatinine of observation group were significantly lower than the control group(t =3.129,9.372,all P ＜ 0.05),while blood pressure,triglycerides,HDL,and 24-hour urinary protein content were significantly higher than control groug(t =7.361,2.398,2.833,all P ＜ 0.05).The FE3 level of the observation group were significantly lower than the control group (t =2.913,P ＜ 0.05).There was a significant positive correlation between the FE3 level of normal pregnant women and their gestational age (r =0.937,P ＜ 0.05).The probabilities of premature birth,premature rupture of membranes,postpartum hemorrhage,and neonatal asphyxia of observation group were significantly higher than amtrol group (x2 =3.912,3.879,4.267,6.935,all P ＜ 0.05).Conclusion There is a significant correlation between hypertensive disorder complicating pregnancy and FE3,which has an important significance on monitoring the health status of pregnant women and the fetal-placental function.
