Role of AMPK in regulation of bile acid metabolism
10.3760/cma.j.issn.1673-4203.2013.01.017
- VernacularTitle:AMPK在胆汁酸代谢中的调节作用
- Author:
Jingyu HE
;
Zhengming LEI
;
Wenguang FU
- Publication Type:Journal Article
- Keywords:
Adenosine monophosphate-activated protein kinase;
Bile acids and salts;
Bile salt export pump;
Steroid receptor coactivator-2;
Leptin
- From:
International Journal of Surgery
2013;(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate-activated protein kinase (AMPK) activation also can inhibit the synthesis of cholesterol and fat.Recent studies have shown that activation of AMPK can also inhibit the synthesis of bile acid and promote bile salt export pump' s generation.All of those illustrated that AMPK played an important role in regulating bile acid metabolism.This article will summarize the AMPK activation pathway,bile acid metabolism,AMPK activity in bile acid synthesis and transfer,and so on.
