Viral microRNA in human cytomegalovirus infection
10.3760/cma.j.issn.1673-4408.2013.02.015
- VernacularTitle:病毒编码微小RNA在人巨细胞病毒感染中的作用
- Author:
Huiping ZHANG
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Human cytomegalovirus
- From:
International Journal of Pediatrics
2013;(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is a class of noncoding small-molecule RNA in eukaryotic cells and certain viruses,which plays a major role in the post-transcriptional level of target-gene regulation.Due to their nonimmunogenic nature,viral miRNA represents an elegant tool for the virus to evade the host immune system,and is likely to play a key role in the latent/Iytic switch during the viral lifecycle.Human cytomegalovirus(HCMV) is a widespread herpesvirus.HCMV-encoded miRNAs play an improtant role in lantent infection by targeting viral and cellular genes.These miRNAs have the potential to become novel biomarkers and targets of treatment.This review summarizes the recent advances of HCMV-encoded miRNA.
