IGF-1 and IGFBP-3 in the safety and efficacy of growth hormone treatment
10.3760/cma.j.issn.1673-4408.2013.02.014
- VernacularTitle:IGF-1和IGFBP-3在生长激素治疗中的安全性和有效性的研究
- Author:
Liping HAO
- Publication Type:Journal Article
- Keywords:
Insulin like growth actor 1;
Insulin like growth factor binding protein 3;
Growth hormone;
Treatment
- From:
International Journal of Pediatrics
2013;(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant human growth hormone (rhGH) has been widely used in clinical treatment of growth hormone deficiency(GHD),and has achieved satisfactory effect.Growth hormone (GH) can stimulate liver cells to produce insulin-like growth actor(IGF-1) which mediated GH growth promoting effect.The majority of IGF-1 combine with insulin like growth factor binding protein 3.IGF-I promotes cell mitotic and inhibit cell apoptosis,in recent years,some scholars have reported that there is a certain relationship between IGF-1 and tumor occurrence and development,and thus leading to the attention to the efficacy and safety of rhGH treatment.
