Progress on the molecular mechanisms of neuroglobin improving neonatal hypoxia-isehemia brain injury
10.3760/cma.j.issn.1673-4408.2013.02.011
- VernacularTitle:脑红蛋白减轻缺氧缺血性脑损伤的机制研究进展
- Author:
Xiaodan CHEN
- Publication Type:Journal Article
- Keywords:
Neuroglobin;
Hypoxia-ischemia;
Brain injury;
Molecular mechanism
- From:
International Journal of Pediatrics
2013;(2):142-144
- CountryChina
- Language:Chinese
-
Abstract:
Neuroglobin is involved in neuroprotection from damage due to hypoxia or ischemia in vitro and in vivo.Overexpression of neuroglobin ameliorates the recovery from hypoxia-ischemia brain injury in experimental animals.The mechanism is still unknown.Studies have revealed that neuroglobin has a typical globin fold,and despite being hexacoordinated,which binds reversibly O2,CO2,and NO.This article reviews the possible mechanisms involved in neuroprotection of neuroglobin and provide a clue in treatment of hypoxia-ischemia brain injury.
