Mechanism of insulin resistance induced by bisphenol A
10.3760/cma.j.issn.1673-4408.2013.02.005
- VernacularTitle:双酚A引起胰岛素抵抗的机制
- Author:
Yuee DAI
- Publication Type:Journal Article
- Keywords:
Bisphenol A;
Insulin resistance;
Environmental endocrine disruptor;
Metabolic syndrome
- From:
International Journal of Pediatrics
2013;(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
Bisphenol A(BPA) is one of the environmental endocrine disruptors with estrogenic properties,and it is also one of the most widespread compounds in the manufacture of polycarbonate plastics.Many studies confirmed that BPA exposure for long-term could lead to obesity,precocious puberty,insulin resistance (IR) et al.IR was defined as the decrease sensitivity in insulin action on the target tissues,which would result in impaired glucose tolerance and diabetes.A number of experiments and clinical investigations found that BPA could induce IR by affecting the function of islet beta cell,glucose transporter and adiponectin secretion.This review aims to summarize the mechanism of IR induced by BPA.
