Expression and clinical significance of FEZ1 and p16 in cervical intraepithelial neoplasia
10.3760/cma.j.issn.1673-4904.2013.12.002
- VernacularTitle:FEZ1和p16在宫颈上皮内瘤变中的表达及临床意义
- Author:
Lining WANG
;
Hui CAI
;
Kexin WEI
;
Huizhong XUE
;
Yulin MA
;
Xinpeng ZHANG
- Publication Type:Journal Article
- Keywords:
Cevical intraepithelial neoplasia;
Immunohistochemistry;
FEZ1
- From:
Chinese Journal of Postgraduates of Medicine
2013;(12):3-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and the relationship of FEZ1 and p16 in cervical intraepithelial neoplasia (CIN).Methods The expressions of FEZ1 and p16 in 93 cases of CIN and 10 cases of normal cervical specimens were detected by immunohistochemistry.Results The positive expression rates of FEZ 1 were 90.0％ (9/10) of normal cervical specimens,67.9％ (19/28) of CIN I,36.0％ (9/25) of CIN Ⅱ,22.5％(9/40) of CIN Ⅲ.The positive expression rates of p16 were 10.0％(1/10) of normal cervical specimens,32.1％(9/28) of CIN I,76.0％(19/25) of CIN Ⅱ,92.5％(37/40) of CIN Ⅲ.There were significant differences in the positive expression rates of FEZ1 and p16 between CIN Ⅰ and CIN Ⅲ (P ＜ 0.01),there was no significant difference in the positive expression rates of FEZ1 and p16 between CIN Ⅱ and CIN Ⅲ.The expression of FEZ1 and p16 was negatively correlation in CIN (r =-0.712,P＜ 0.01).Conclusion The abnormal high expression of p16 and abnormal low expression of FEZ1 in CIN may be involved in the occurrence and development of CIN,detecting the expressions of the two indexes may be helpful for clinical diagnosis.
