The variation of N400 event-related potentials during language cognition of different paradigms in stroke patients
10.3760/cma.j.issn.0254-1424.2013.01.002
- VernacularTitle:脑卒中患者不同语言范式下语言认知N400的差异
- Author:
Jing HAN
;
Hua LI
- Publication Type:Journal Article
- Keywords:
Stroke;
Language cognition;
Event-related potentials;
N400
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2013;(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cognition processes of language in stroke patients by characterizing the differences between the event-related potentials (ERPs) N400 evoked bypicture-word andsentence-wordparadigms.Methods Twenty patients with a single brain lesion resulting from a first episode of stroke were tested along with 20 normal controls.Their N400 ERPs were tested using pictures and sentences as activating stimuli and phrases composed of nouns and verbs as the target stimuli.The N400 potentials were recorded from electrodes located at Fz,Pz,T3 and T4 positions of the International 10-20 system.The N400 latencies and amplitudes and the behavioral responses of the experimental and control groups were compared.Results The latencies were longer and the amplitudes were lower in response to sentence activation than to picture activation.The differences in terms of amplitude were the greatest with N400 recorded from Pz.The responses to the target stimuli were not significantly different with regard to the types of stimuli and recording location.The average response time was longer and the error rate was higher in response to sentence activation than to picture activation.Conclusion Multiple accesses,activating stimuli and integrating processes are involved in language cognition.The brain is more sensitive and accurate in response to picture stimuli in language cognition.The response to sentence stimuli is slower,and the error rate is higher.This suggests that it is better to usc varied prime stimuli in teaching children languages.
