Serum screening of celiac disease in Chinese adults with diarrhea-predominant irritable bowel syndrome in Hubei, China
10.3760/cma.j.issn.0578-1426.2013.01.010
- VernacularTitle:中国湖北地区腹泻型肠易激综合征患者中成人乳糜泻血清学筛查
- Author:
Hongling WANG
;
Linjie LUO
;
Jiguang KOU
;
Anlong YUAN
;
Guifang YANG
;
Min WANG
;
Bing XIA
- Publication Type:Journal Article
- Keywords:
Celiac disease;
Irritable bowel syndrome;
Prevalence;
Biological markers
- From:
Chinese Journal of Internal Medicine
2013;(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen the prevalence of celiac disease with serologic markers in the central Chinese population,specifically in patients with chronic diarrhea-predominant irritable bowel syndrome (D-IBS).Methods A total of 282 adult patients with D-IBS were selected based on ROME Ⅲ criteria with 296 age and sex matched consecutive healthy individuals as controls.A gluten-free diet (GFD) was advised in subjects positive for IgA/IgG anti-htTG/DGP antibodies and the serologic antibodies were retested after the GFD.Results Among the 578 study subjects,five D-IBS patients (5/282,1.77％) and two healthy controls (2/296,0.68％) were positive for anti-htTG/DGP antibodies.Among the seven positive cases,one was lost to follow-up and only four were evaluated during GFD therapy for an average of 5.2 months with clinical and/or serological manifestations improved.Conclusions The prevalence of celiac disease may not be uncommon in China.Compared with the healthy population,patients with D-IBS tend to be affected more.Thus,it is significantly important to conduct routine screening for celiac disease in patients with D-IBS.
