Correlation of thyroid-stimulating hormone with NF-κB p65 and TNF-α in adipocytes
10.3760/cma.j.issn.1000-6699.2013.03.018
- VernacularTitle:TSH与脂肪细胞NF-κB、肿瘤坏死因子-α蛋白水平相关性的研究
- Author:
Yajing ZHANG
;
Wei ZHAO
;
Hong ZHANG
;
Xiaoming WU
;
Jia LIU
;
Lin ZHANG
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Adipocyte;
Thyroid-stimulating hormone;
Tumor necrosis factor-alpha;
Nuclear factor-kappa B
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(3):257-259
- CountryChina
- Language:Chinese
-
Abstract:
Serum TSH level was determined by Enzvme-Linked Immunosorbent Assay (ELISA).The expression of NF-κB p65 and tumor necrosis factor-α (TNF-α) were quantified by Western blotting.The results showed that serum TSH concentration was positively correlated with the expression of NF-κB p65 and TNF-α,and negatively correlated with insulin activity index.The levels of TNF-α and NF-κB p65 both were increased by TSH in a dose dependent manner(P＜0.05).
