The relationship between association of microalbuminuria and retinal vessel diameter in population with essential hypertension
10.3760/cma.j.issn.0578-1426.2013.04.012
- VernacularTitle:高血压人群微量蛋白尿与眼底血管直径的关系
- Author:
Qiuxia HUANG
;
Pengli ZHU
;
Feng HUANG
;
Fan LIN
;
Zhonghai GAO
;
Falin CHEN
;
Jiangang HUANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Proteinuria;
Retinal artery
- From:
Chinese Journal of Internal Medicine
2013;(4):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of urinary albumin-to-creatinine ratio (UACR) and the diameter of retinal vessel in population with essential hypertension in Fujian coastal area.Methods Central retinal artery and vein equivalents (CRAE and CRVE) were measured from the avoiding mydriatic digitized photographs and semi-automatic fundus analysis software,as well as albumin and urine creatinine.Results There were significant differences in CRAE levels among the normal control group,normoalbuminuria with essential hypertension group and microalbuminuria with essential hypertension group [(135.68 ± 10.10) μm,(129.79 ± 10.48) μm,(125.29 ± 11.17) μm,all P values ＜0.01].The CRAE levels were significantly negative correlated with UACR (r =-0.29,P ＜ 0.01).Linear regression analysis showed CRAE was associated with UACR in the patients with hypertension(β =-5.0,P ＜ 0.01).Logistic regression analysis showed,systolic blood pressure (β =1.08,P =0.02) was risk factor for CRAE abnormality.The CRAE abnormality was increased in turn in the normal control group,normoalbuminuria with the essential hypertension group and microalbuminuria with essential hypertension group (P ＜ 0.01).Conclusion The reduction of central retinal artery diameter are associated with the hypertensive renal damage.UACR and CRAE could be used to evaluate the microvascular lesions and be used as an indicator to assess the target organs damage in essential hypertension patients.
