Glycosylated hemoglobin A1c for the diagnosis of diabetes mellitus: a meta-analysis

VernacularTitle:糖化血红蛋白对中国人群糖尿病诊断价值的Meta分析
Author: Songtao TANG ; Qiu ZHANG ; Changjiang WANG ; Haiqin TANG ; Taixiang WU
Publication Type:Journal Article
Keywords: Diabetes mellitus; Diagnosis; Hemoglobin A,glycosylated; Meta-analysis
From: Chinese Journal of Internal Medicine 2013;(1):21-25
CountryChina
Language:Chinese
Abstract: Objective To assess the diagnostic value of glycosylated hemoglobin A1c (HbA1c) ≥6.5％ for diabetes in Chinese adults with oral glucose tolerance test(OGTT) as the reference standard.Methods Major databases were searched to get all diagnostic tests with HbA1c ≥ 6.5％ for diabetes in Chinese adults.QUADAS items were used to evaluate the quality of the eligible studies.Meta-disc software was used to perform comprehensive quantitative assessment for all included studies and summary ROC (SROC) curve were drawn.Results A total of 11 studies were included.The outcomes of the diagnostic value with HbA1c ≥6.5％ were as the following:pooled sensitivity 0.62 (95％ CI:0.60-0.64),pooled specificity 0.96 (95％ CI:0.95-0.96),diagnostic odds ratio (DOR) 40.25 (95％ CI:20.79-77.95) and AUCSROC 0.7702 (sx =0.0636).Conclusions The diagnostic specificity is pretty high for the diagnostic test with HbA1c ≥6.5％,while sensitivity is low.Combination of HbA1c and glucose tests is needed to reduce the missed diagnosis rate.