Cholesterol ester transfer protein regulates the hepatic SR-B1 mRNA expression in mice
10.3760/cma.j.issn.1000-6699.2013.03.019
- VernacularTitle:胆固醇酯转运蛋白对小鼠肝脏SR-B1基因表达的调控
- Author:
Wen GUO
;
Tao YANG
;
Zhenzhen FU
;
Yan SUN
;
Xiaohui ZHU
;
Beibei GAO
;
Hongwen ZHOU
- Publication Type:Journal Article
- Keywords:
Cholesterol ester transfer protein;
Low density lipoprotein receptor;
Scavenger receptor class B typeⅠ
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(3):259-260
- CountryChina
- Language:Chinese
-
Abstract:
The effect of cholesterol ester transfer protein(CETP) on SR-B1 mRNA expression in mouse liver was investigated.The results demonstrated that CETP transgenic mice showed lower serum total cholesterol and high density lipoprotein-cholesterol levels but higher total cholesterol and cholesterol ester content in liver when compared with wild type mice(P＜0.05).The expression of SR-B1 mRNA in liver of CETP transgenic mice was significantly lower as compared with the control group(P＜0.05).
