Final adult height of girls with central precocious puberty or early and fast puberty could be improved by treatment of gonadotropin-releasing hormone analogs
10.3760/cma.j.issn.1000-6699.2013.03.011
- VernacularTitle:促性腺激素释放激素类似物改善中枢性性早熟和快速进展型早发育女孩成年身高:单中心15年102例病例追踪研究
- Author:
Qiuli CHEN
;
Huamei MA
;
Yanhong LI
;
Zhe SU
;
Hongshan CHEN
;
Minlian DU
- Publication Type:Journal Article
- Keywords:
Central precocious puberty;
Early and fast puberty;
Gonadotropin-releasing hormone analogs;
Final adult height
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(3):236-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and impact factors of treatment with Gonadotropin-releasing hormone analogs (GnRHa) in central precocious puberty (CPP) or early and fast puberty (EFP) girls in a retrospective unicenter study.Methods One hundred and two girls (75 CPP and 27 EFP) were treated with GnRHa alone and were followed up to their final adult hight (FAH).Results FAH was (158.0 ± 4.8) cm,being significantly higher than pretreatment predicted adult height [(151.1 ±5.1) cm,P＜0.01].There was no significant difference between CPP [(7.3 ± 4.4) cm] and EFP [(5.5 ± 4.5) cm] in net height gain.There was no significant improvement in FAH and pretreatment PAH for the patients who had menarche before treatment or whose growth velocity was less than 4 cm during the first year.Conclusion GnRHa treatment improves FAH efficiently for both CPP and EFP girls.Nevertheless,those who had menarche before treatment or whose growth velocity was less than 4 cm during the first year can hardly improve FAH by GnRHa treatment alone.
